Systemic lupus erythematosus and pregnancy

( views:475, downloads:0 )
Author:
CHEN Hong-xiang(Department of Dermatology, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China)
WU Zhi-hong(Department of Dermatology, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China)
TU Ya-ting(Department of Dermatology, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China)
Journal Title:
INTERNATIONAL JOURNAL OF DERMATOLOGY AND VENEREOLOGY
Issue:
Volume 34, Issue 04, 2008
DOI:
Key Word:
Lupus erythematosus, systemic;Pregnancy;Immunosuppressive agents

Abstract: Systemic lupus erythematosus (SLE)predilects in women in child-bearing period,who unavoidably face problems of procreation. Nowadays, pregnancy is no longer looked as contraindication in SLE patients. Pregnancy may induce or even aggravate SLE, and SLE could affect the process and outcome of pregnancy, even lead to abortion, fetal death, stillbirth, fetal growth restriction or induce the development of neonatal lupus erythematosus (NLE). So it is important for clinicians to learn the changes in immunology and hormone levels in women with SLE that may contribute to pregnancy and fetus, to be knowledgeable about the indication for SLE patients to be pregnant, to apply effective immunosuppressants and right care, and to control patients' condition so as to ensure normal pregnancy and childbirth.

  • [1]Castaneda Ospina SA,Cardona Maya WD,Bueno Sanchez JC,et al.Pregnancy outcome in women with antiphospholipid syndrome and alloimmunity:a case report.Sao Paulo Med J,2003,121 (6):248-250.
  • [2]Ogishima D,Matsumoto T,Nakamura Y,et al.Placental pathology in systemic lupus erythematosus with antiphospholipid antibodies.Pathol Int,2000,50(3):224-229.
  • [3]苏厚恒,吴宁,李凝.系统性红斑狼疮患者与分娩过程处理的初步探讨.中华风湿病学杂志,2004,8(5):299-301.
  • [4]Yukiko N.Immune responses to SS-A 52-kDa and 60-kDa proteins and to SS-B 50-kDa protein in mothers of infants with neonatal lupus erythematosus.Br J Dermatol,2000,142(5):908.
  • [5]De Bandt M,Palazzo E,Belmatoug N,et al.Outcome of pregnancies in lupus:experience at one center.Ann Med Interne (Paris),2000,151(2):87-92.
  • [6]Ruiz-Irastorza G,Khamashta MA.Evaluation of systemic lupus erythematosus activity during pregnancy.Lupus,2004,13 (9):679.
  • [7]Sangle S,D'Cruz DP,Hughes GR.Livedo reticularis and pregnancy morbidity in patients negative for antiphospholipid antibodies.Ann Rheum Dis,2005,64(1):147-148.
  • [8]Bizzaro N,Tonutti E,Villalta D,et al.Prevalence and clinical correlation of anti-phospholipid-binding protein antibodies in anticardiolipin-negative patients with systemic lupus erythematosus and women with unexplained recurrent miscarriages.Arch Pathol Lab Med,2005,129(1):61-68.
  • [9]Dhar JP,Sokol RJ.Lupus and pregnancy:complex yet manageable.Clin Meal Res,2006,4(4):310-321.
  • [10]任华,汪凤鸣.妊娠合并系统性红斑狼疮及对母婴影响.中国优生与遗传杂志,2000,8(4):122-212.
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn