Advances in the treatment of skin diseases with δ-aminolevulinic acid-based photodynamic therapy

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Author:
XIA Yu-min(Department of Dermatology,Renmin Hospital of Wuhan University,Wuhan 430060,China)
XU Shi-zheng(Department of Dermatology,Renmin Hospital of Wuhan University,Wuhan 430060,China)
Journal Title:
INTERNATIONAL JOURNAL OF DERMATOLOGY AND VENEREOLOGY
Issue:
Volume 34, Issue 03, 2008
DOI:
Key Word:
Aminolevulinic acid;Photochemotherapy;Skin diseases

Abstract: δ-aminolevulinic acid(ALA)-based photodynamic therapy(PDT)is a noninvasive topical treatment choice that can selectively kill target cells.One important mechanism for its therapeutic effect is to intluence some biological characteristics of target cells.Besides nonpigment cell malignant tumors of skin,ALA-PDT could be used in the treatment of premalignant lesions,viral warts,acne,connective tissue diseases,actinic skin diseases,and SO on.Appropriate higher temperature,cosolvents,metal chelating agents.iontoplaoretic delivery and liposome vector may enhance the therapeutic efrect of ALA-PDT.

  • [1]Akita Y,Kozaki K,Nakagawa A,et al.Cyclooxygenase-2 is a possible target of treatment approach in conjunction with photodynamic therapy for various disorders in skin and oral cavity.Br J Dermatol,2004,151(2):472-480.
  • [2]Karrer S,Bosserhoff AK,Weiderer P,et al.Keratinocyte-derived cytokines after photodynamic therapy and their paracrine induction of matrix metalloproteinases in fibroblasts.Br J Dermatol,2004,151(4):776-783.
  • [3]de Bruijn HS,Kruijt B,van der Ploeg-van den Heuvel A,et al.Increase in protoporphyrin Ⅸ after 5-aminolevulinic acid based photodynamic therapy is due to local re-synthesis.Photochem Photobiol Sci,2007,6(8):857-864.
  • [4]Hayami J,Okamoto H,Sugihara A,et al.Immunosuppressive effects of photodynamic therapy by topical aminolevulinic acid.J Dermatol,2007,34(5):320-327.
  • [5]Kosaka S,Kawana S,Zouboulis CC,et al.Targeting of sebocytes by aminolevulinic acid-dependent photosensitization.Photochem Photobiol,2006,82(2):453-457.
  • [6]Wang XL,Wang HW,Wang HS,et al.Topical 5-aminolaevulinic acid-photodynamic therapy for the treatment of urethral condylomata acuminata.Br J Dermatol,2004,151 (4):880-885.
  • [7]Wang YS,Tay YK,Kwok C,et al.Photodynamic therapy with 20% aminolevulinic acid for the treatment of recalcitrant viral warts in an Asian population.Int J Dermatol,2007,46 (11):1180-1184.
  • [8]Gold MH,Boring MM,Bridges TM,et al.The successful use of ALA-PDT in the treatment of recalcitrant molluscum contagiosum.J Drugs Dermatol,2004,3(2):187-190.
  • [9]Akilov OE,Kosaka S,O'Riordan K,et al.Parasiticidal effect of delta-aminolevulinic acid-based photodynamic therapy for cutaneous leishmaniasis is indirect and mediated through the killing of the host cells.Exp Dermatol,2007,16 (8):651-660.
  • [10]Alexiades-Armenakas MR,Geronemus RG.Laser-mediated photodynamic therapy of actinic cheilitis.J Drugs Dermatol,2004,3(5):548-551.
  • [11]Wolfe CM,Hatfield K,Cognetta AB Jr.Cellulitis as a postprocedural complication of topical 5-aminolevulinic acid photodynamic therapy in the treatment of actinic keratosis.J Drugs Dermatol,2007,6(5):544-548.
  • [12]Kerr AC,Ferguson J,Ibbotson SH.Acute phototoxicity with urticarial features during topical 5-aminolaevulinic acid photodynamic therapy.Clin Exp Dermatol,2007,32(2):201-202.
  • [13]van den Akker JT,Boot K,Vernon DI,et al.Effect of elevating the skin temperature during topical ALA application on in vitro ALA penetration through mouse skin and in vivo PpⅨ production in human skin.Photochem Photobiol Sci,2004,3 (3):263-267.
  • [14]Yanase S,Nomura J,Matsumura Y,et al.Synergistic interaction of 5-aminolevulinic acid-based photodynamic therapy with simultaneous hyperthermia in an osteosarcoma tumor model.Int J Oncol,2006,29(2):365-373.
  • [15]Boddé HE,Roemelé PE,Star WM.Quantification of topically delivered 5-aminolevulinic acid by lontophoresis across ex vivo human stratum corneum.Photochem Photobiol,2002,75(4):418-423.
  • [16]de Haas ER,Knfijt B,Sterenborg HJ,et al.Fractionated illumination significantly improves the response of superficial basal cell carcinoma to aminolevulinic acid photodynamic therapy.J Invest Dermatol,2006,126(12):2679-2686.
  • [17]Auner BG,Valenta C,Hadgraft J.Influence of lipophilic counter-ions in combination with phloretin and 6-ketocholestanol on the skin permeation of 5-aminolevulinic acid.Int J Pharm,2003,255(1-2):109-116.
  • [18]Christiansen K,Bjerring P,Troilius A.5-ALA for photodynamic photorejuvenation-optimization of treatment regime based on normal-skin fluorescence measurements.Lasers Surg Med,2007,39(4):302-310.
  • [19]Uehlinger P,Ballini JP,van den Bergh H,et al.On the role of iron and one of its chelating agents in the production of protoporphyrin Ⅸ generated by 5-aminolevulinic acid and its hexyl ester derivative tested on an epidermal equivalent of human skin.Photochem Photobiol,2006,82(4):1069-1076.
  • [20]Liu HF,Xu SZ,Zhang CR.Influence of CaNa2 EDTA on topical 5-aminolaevulinic acid photodynamic therapy.Chin Med J (Engl),2004,117(6):922-926.
  • [21]Pye A,Curnow A.Direct comparison of delta-aminolevulinic acid and methyl-aminolevulinate-derived protoporphyrin Ⅸ accumulations potentiated by desferrioxamine or the novel hydroxypyridinone iron chelator CP94 in cultured human cells.Photochem Photobiol,2007,83 (3):766-773.
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