Advances in the treatment of skin diseases with δ-aminolevulinic acid-based photodynamic therapy

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XIA Yu-min(Department of Dermatology,Renmin Hospital of Wuhan University,Wuhan 430060,China)
XU Shi-zheng(Department of Dermatology,Renmin Hospital of Wuhan University,Wuhan 430060,China)
Journal Title:
Volume 34, Issue 03, 2008
Key Word:
Aminolevulinic acid;Photochemotherapy;Skin diseases

Abstract: δ-aminolevulinic acid(ALA)-based photodynamic therapy(PDT)is a noninvasive topical treatment choice that can selectively kill target cells.One important mechanism for its therapeutic effect is to intluence some biological characteristics of target cells.Besides nonpigment cell malignant tumors of skin,ALA-PDT could be used in the treatment of premalignant lesions,viral warts,acne,connective tissue diseases,actinic skin diseases,and SO on.Appropriate higher temperature,cosolvents,metal chelating agents.iontoplaoretic delivery and liposome vector may enhance the therapeutic efrect of ALA-PDT.

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