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Immunopathogenesis and immunotherapy of severe bullous drug eruptions
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- Author:
- No author available
- Journal Title:
- INTERNATIONAL JOURNAL OF DERMATOLOGY AND VENEREOLOGY
- Issue:
- 2
- DOI:
- 10.3760/cma.j.issn.1673-4173.2008.02.002
- Key Word:
- 药疹;Stevens-Johnson综合征;表皮坏死松解症,中毒性;免疫疗法
Abstract： 重症大疱性药疹,包括重症多形红斑、Stevens-Johnson综合征、中毒性表皮坏死松解症,是皮肤科最严重的疾病之一.近年对其发病的免疫机制有新的认识,主要是在Fas-FasL介导的细胞凋亡、细胞毒T细胞的作用、肿瘤坏死因子-α诱导凋亡及线粒体的损伤方面.在临床治疗中可应用免疫治疗药物,如静脉滴注丙种球蛋白、环孢素、沙利度胺及抗肿瘤坏死因子单克隆抗体等.
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