Dendritic cell vaccination for malignant melanoma

( views:, downloads: )
LI Run-xiang()
FENG Cheng-en()
WU Zhi-hua()
LI Shun-fan()
Journal Title:
Volume 33, Issue 03, 2007
Key Word:


  • [1]Liu YJ.Dendritic cell subsets and lineages,and their functions in innate and adaptive immunity.Cell,2001,106 (3):259-262.
  • [2]Fernandez NC,Lozier A,Flament C,et al.Dendritic cells di rectly trigger NK cell functions:cross-talk relevant in innate anti-tumor immune responses in vivo.Nat Med,1999,5(4):405-411.
  • [3]Wallet MA,SenP,Tisch R.Immunoregulation of dendritic cells.Clin Med Res,2005,3(3):166-175.
  • [4]Germeau C,Ma W,Schiavetti F,et al.High frequency of antitu-mor T cells in the blood of melanoma patients before and after vaccination with tumor antigens.J Exp Med,2005,201 (2):241-248.
  • [5]Schmitz M,Zhao S,Deuse Y,et al.Tumoricidal potential of native blood dendritic cells:direct tumor cell killing and activation of NK cell-mediated cytotoxicity.JImmunol,2005,174 (7):4127-4134.
  • [6]Nestle FO,Alijagic S,Gilliet M,et al.Vaccination of melanoma patients with peptide-or tumor lysate-pulsed dendritic cells.Nat Med,1998,4(3):328-332.
  • [7]Thumer B,Haendle I,Roder C,et al.Vaccination with mage-3Al peptide-pulsed mature,monocyte-derived dendritic cells expands specific cytotoxic T cells and induces regression of some metastases in advanced stage IV melanoma.J Exp Med,1999,190(11):1669-1678.
  • [8]Meidenbauer N,Andreesen R,Mackensen A.Dendritic cells for specific cancer immunotherapy.Biol Chem,2001,382(4):507-520.
  • [9]Krause SW,Neumann C,Soruri A,et al.The treatment of patients with disseminated malignant melanoma by vaccination with autologous cell hybrids of tumor cells and dendritic cells.J Immunother,2002,25 (5):421-428.
  • [10]Morse MA,Coleman RE,Akabani G,et al.Migration of human dendritic cells after injection in patients with metastatic malignancies.Cancer Res,1999,59 (1):56-58.
  • [11]Mackensen A,Herbst B,Chen JL,et al.Phase 1 study in melanoma patients of a vaccine with peptide-pulsed dendritic cells generated in vitro from CD34 (+) hematopoietic progenitor cells.Int J Cancer,2000,86 (3):385-392.
  • [12]Triozzi PL,Khurram R,Aldrich WA,et al.Intratumoral injection of dendritic cells derived in vitro in patients with metastatic cancer.Cancer,2000,89 (12):2646-2654.
  • [13]Fong L,Brockstedt D,Benike C,et al.Dendritic cell-based xenoantigen vaccination for prostate cancer immunotherapy.J Immunol,2001,167 (12):7150-7156.
  • [14]Serody JS,Collins EJ,Tisch RM,et al.T cell activity after dendritic cell vaccination is dependent on both the type of antigen and the mode of delivery.J Immunol,2000,164 (9):4961.
  • [15]Schuler-Thumer B,Schultz ES,Berger TG,et al.Rapid induction of tumor-specific type 1 T helper cells in metastatic melanoma patients by vaccination with mature,cryopreserved,peptide-loaded monocyte-derived dendritic cells.J Exp Med,2002,195(10):1279-1288.
  • [16]Butterfield LH,Ribas A,Dissette VB,et al.Determinant spreading associated with clinical response in dendritic cell-based immunotherapy for malignant melanoma.Clin Cancer Res,2003,9(3):998-1008.
  • [17]O'Rourke MG,Johnson M,Lanagan C,et al.Durable complete clinical responses in a phase 1/11 trial using an autologous melanoma cell/dendritic cell vaccine.Cancer Immunol Immunother,2003,52 (6):387-395.
  • [18]Schuler-Thurner B,Dieckmann D,Keikavoussi P,et al.Mage-3 and influenza-matrix peptide-specific cytotoxic T cells are inducible in terminal stage HLA-A2.1+ melanoma patients by inature monocyte-derived dendritic cells.J Immunol,2000,165 (6):3492-3496.
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615