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Advances in immunology of lichen sclerosus et atrophicus
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- Author:
- No author available
- Journal Title:
- INTERNATIONAL JOURNAL OF DERMATOLOGY AND VENEREOLOGY
- Issue:
- 2
- DOI:
- 10.3760/cma.j.issn.1673-4173.2007.02.003
- Key Word:
- 硬化萎缩苔藓;免疫;血管;基底膜
Abstract： 硬化萎缩性苔藓是一种慢性持续性炎症性皮肤病,其发病与自身免疫密切相关,硬化萎缩性苔藓患者皮肤活检组织中存在免疫学改变:血管炎表现,基底膜的不连续性,单克隆T细胞受体γ链重排;外周血中的免疫学改变:CD4+CD25+调节性T细胞及细胞因子的增多,抗基底膜抗体、抗细胞外基质糖蛋白-1抗体的发现都提示免疫学改变在硬化萎缩性苔藓发生发展中有着重要的作用.
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