Role of Estrogen and Its Receptors in the Pathogenesis of SLE

( views:, downloads: )
FAN Yi()
CHEN Hong()
Journal Title:
Volume 32, Issue 06, 2006
Key Word:


  • [1]Folomeev M,Dougados M,Beaune J,et al.Plasma sex hormones and aromatase activity in tissues of patients with systemic lupus erythematosus.Lupus,1992,1:191-195.
  • [2]McMurray RW,May W.Sex hormones and systemic lupus erythematosus:review and meta-analysis.Arthritis Rheum,2003,48:2100-2110.
  • [3]Munoz JA,Gil A,Lopez-Dupla JM,et al.Sex hormones in chronic systemic lupus erythematosus.Correlation with clinical and biological parameters.Ann Med Interne (Paris),1994,145:459-463.
  • [4]Chang DM,Lan JL,Lin HY,et al.Dehydroepiandrosterone treatment of women with mild-to-moderate systemic lupus erythematosus:a multicenter randomized,double-blind,placebo-controlled trial.Arthritis Rheum,2002,46:2924-2927.
  • [5]Mor G,Munoz A,Redlinger R Jr,et al.The role of the Fas/Fas ligand system in estrogen-induced thymic alteration.Am J Reprod Immunol,2001,46:298-307.
  • [6]Handwerger BS,Rus V,da Silva L,et al.The role of cytokines in the immunopathogenesis of lupus.Springer Semin Immunopathol,1994,16:153-180.
  • [7]Kanda N,Tamaki K.Estrogen enhances immunoglobulin production by human PBMCs.J Allergy Clin Immunol,1999,103 (2 Pt 1):282-288.
  • [8]Rider V,Jones S,Evans M,et al.Estrogen increases CD40 ligand expression in T cells from women with systemic lupus erythematosus.J Rheumatol,2001,28:2644-2649.
  • [9]Bynoe MS,Grimaldi CM,Diamond B.Estrogen up-regulates Bcl-2and blocks tolerance induction of naive B cells.Proc Natl Acad Sci U S A,2000,97:2703-2708.
  • [10]Kojima T,Horiuchi T,Nishizaka H,et al.Analysis of fas ligand gene mutation in patients with systemic lupus erythematosus.Arthritis Rheum,2000,43:135-139.
  • [11]Rider V,Abdou NI.Gender differences in autoimmunity:molecular basis for estrogen effects in systemic lupus erythematosus.Int Immunopharmacol,2001,1:1009-1024.
  • [12]Feng S.Estrogen receptor content of peripheral blood lymphocytes in patients with systemic lupus erythematosus.Zhonghua Yi Xue Za Zhi,1991,71:1-3,2.
  • [13]Johansson M,Arlestig L,Moller B,et al.Oestrogen receptor (alpha)gene polymorphisms in systemic lupus erythematosus.Ann Rheum Dis,2005,64:1611-1617.
  • [14]Lee YJ,Shin KS,Kang SW,et al.Association of the oestrogen receptor alpha gene polymorphisms with disease onset in systemic lupus erythematosus.Ann Rheum Dis,2004,63:1244-1249.
  • [15]Liu ZH,Cheng ZH,Gong RJ,et al.Sex differences in estrogen receptor gene polymorphism and its association with lupus nephritis in Chinese.Nephron,2002,90:174-180.
  • [16]Dhaher YY,Greenstein B,de Fougerolles Nunn E,et al.Strain differences in binding properties of estrogen receptors in immature and adult BALB/c and MRL/MP-lpr/lpr mice,a model of systemic lupus erythematosus.Int J Immunopharmacol,2000,22:247-254.
  • [17]Gu Q,Moss RL.Novel mechanism for non-genomic action of 17beta-oestradiol on kainate-induced currents in isolated rat CA1hippocampal neurones.J Physiol,1998,506 (Pt 3):745-754.
  • [18]Luconi M,Bonaccorsi L,Forti G,et al.Effects of estrogenic compounds on human spermatozoa:evidence for interaction with a nongenomic receptor for estrogen on human sperm membrane.Mol Cell Endocrinol,2001,178:39-45.
  • [19]Pappas TC,Gametchu B,Watson CS.Membrane estrogen receptors identified by multiple antibody labeling and impeded-ligand binding.FASEB J,1995,9:404-410.
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615