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Histone modification and neural stem cell differentiation

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Author:: No author available

Journal Title:: International Journal of Cerebrovascular Diseases

Issue:: 9

DOI:: 10.3760/cma.j.issn.1673-4165.2012.09.011

Key Word:: 组蛋白;甲基化;神经元;干细胞;细胞分化;Histones;Methylation;Neurons;Stem Cells;Cell Differentiation

Abstract： Neural stem cell (NSC) has self-renewal and differentiation potential.It can orderly differentiate into neurons,astrocytes and oligodendrocytes in the development of central nervous system.NSC differentiation was commonly regulated by a variety of factors,including cytokines,transcription factors and epigenetic factors.Epigenetic regulation is a heritable gene expression without changing the DNA sequence.Histone modification is an important regulation mode in epigenetic modifications,which is essential in the transcription process.It also plays a critical role in the development of central nervous system.This article briefly reviews the histone methylation and demethylafion in the regulation of NSC differentiation.

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