Abstract： Objectives To investigate the change before and after treatment of 24h urinary protein 、SCr and BP in chronic rejection of kidney transplant patients.Methods 70 kidney transplant patients in chronic rejection treated with anti-rejection were selected as observation group,and 70 kidney transplant patients without chronic rejection as control group,then the 24h urinary protein,SCr and BP of the two groups before and after the treatment were studied and compared.Results The 24h urinary protein,SCr and BP of the observation group before the treatment were higher than those of control group,and the levels after the treatment at 24 hours declined,and almost equal to those of control group( P ＜ 0.01 ).There were significant or very significant differences.Conclusions The change of the 24h urinary protein,SCr and BP in the kidney transplant patients in chronic rejection treated with anti-rejection is regular,chronic rejection combined with the treatment of anti-rejection should decrease the levels.