Research on down-regulated expression of MIR-187 in human renal carcinoma
- Author:
- No author available
- Journal Title:
- International Journal of Urology and Nephrology
- Issue:
- 5
- DOI:
- 10.3760/cma.j.issn.1673-4416.2012.05.002
- Key Word:
- 肾肿瘤;RNA;Kidney Neoplasms;RNA
Abstract： Objectives To explore the role of microRNA-187 ( MIR-187 ) in the development of renal cell carcinoma(RCC).Methods On the basis of large-scale parallel sequencing results,We investigated the expression of MIR-187 in human kidney cancer tissues and matched adjacent normal tissues from 54 patients with RCC by using Real-Time quantitative PCR technology( RT-qPCR) and analyzing the correlation between MIR -187 expression and the clinical characteristics of patients with RCC.Results Compared with the matched adjacent normal tissues,miR-187 was significantly down-regulated in RCC.The expression of miRNA-187 was lower in 41 cases of carcinoma tissue out of 54 specimens,while there was higher expression of miRNA-187 in the rest 13 cases.We found a statistically significant lower expression of miRNA-187 in renal carcinoma.Conclusions Low expression of miRNA-187 in renal carcinoma indicates that it might have association with the occurrence of RCC and miRNA-187 may serve as a new and promising target for the diagnosis and treatment of renal carcinoma.
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