Effects of continuous posittive airway pressure therapy on the concentrations of leptin in exhaled breath condensate and blood of patients with obstructive sleep apnea-hypopnea syndrome
- Author:
- No author available
- Journal Title:
- International Journal of Respiration
- Issue:
- 19
- DOI:
- 10.3760/cma.j.issn.1673-436X.2012.019.007
- Key Word:
- 阻塞性睡眠呼吸暂低通气综合征;持续气道正压通气治疗;瘦素;Obstructive sleep apnea-hypopnea syndrome;Continuous positive airway pressure;Leptin
Abstract： Objective To investigate the effect of auto-CPAP therapy on the concentrations of leptin in exhaled breath condensate and plasma in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS).Methods 42 patients with moderate-to-severe OSAHS diagnosed by polysomnograpgy monitoring were randomly allocated to the active group (n =22) or the control group (n =20) respectively.The active group received the treatment of three months' auto-CPAP and all of the subjects received general treatment.Leptin levels in EBC and plasma were measured by enzyme linked immunosorbent assay (ELISA) before and after 3 months.Results ①The concentrations of leptin in EBC and plasma in the active group before treatment [(5.67± 1.07) μg/L,(40.20 ± 5.40) μg/L] were higher than the after [(3.75 ± 1.09) μg/L,(30.46 ± 5.82) μg/L].②The concentrations of leptin in EBC and plasma in the control group before treatment were[(5.52 ±1.14) μg/L,(42.19±4.96) μg/L] and were [(5.95± 1.26) μg/L,(42.69 ± 4.33) μg/L] after the treatment.But there was no statistical difference tetween the before and after the treatment.③Leptin levels in plasma and EBC were positively related with apnea hypoventilation index(AHI),and were inversely related with the lowest blood oxygen saturatin (r =-0.829,P＜0.01.r =0.794,P ＜0.01)and average blood oxygen saturation (r=-0.890,P＜0.01.r =-0.830,P ＜0.01).Conclusions The hyperleptinemia in OSAHS patients and can be improved by auto-CPAP treatment.
- [1]黄蓉,肖毅,钟旭,等.阻塞性睡眠呼吸暂停低通气综合征与高血压及瘦素的关系[J].2010,(2).
- [2]王实,陈雷,刘放,等.CPAP治疗OSA前后血清瘦素及胃饥饿素变化临床观察[J].2007,(3).
- [3]颜光涛,郝秀华,薛辉,等.血清瘦素在手术创伤后应激反应中的变化[J].2006,(3).
- [4]中华医学会呼吸病学分会睡眠呼吸疾病学组.阻塞性睡眠呼吸暂停低通气综合征诊治指南（草案）[J].2002,(4).
- [5]Ulukavak Ciftci T,Bilgihan A,Kokturk O,etc.Leptin and ghrelin levels in patients with obstructive sleep apnea syndrome.[J].2005,72(4).
- [6]Manousaki A,Nikita D,Kryger M,etc.Association of sleep apnea severity and obesity with insulin resistance, C-reactive protein, and leptin levels in male patients with obstructive sleep apnea.[J].2008,186(4).
- [7]B G, Phillips,M, Kato,K, Narkiewicz,etc.Increases in leptin levels, sympathetic drive, and weight gain in obstructive sleep apnea.[J].2000,279(1).
- [8]Schwartz AR,Sorkin JD,Goldberg AP,etc.Sleep-disordered breathing and insulin resistance in middle-aged and overweight men.[J].2002,165(5).
- [9]Hauswirth DW,Sundy JS,Mervin-Blake S,etc.Normative values for exhaled breath condensate pH and its relationship to exhaled nitric oxide in healthy African Americans.[J].2008,122(1).
- [10]Marta, Kumor,Piotr, Bielicki,Tadeusz, Przyby?owski,etc.[Three month continuous positive airway pressure (CPAP) therapy decreases serum total and LDL cholesterol, but not homocysteine and leptin concentration in patients with obstructive sleep apnea syndrome (OSAS)].[J].2011,79(3).
- [11]Molcanyiova A,Tkacova R,Dorkova Z,etc.Effects of continuous positive airway pressure on cardiovascular risk profile in patients with severe obstructive sleep apnea and metabolic syndrome.[J].2008,134(4).
- [12]Eun YG,Shin SY,Kim SW,etc.Short-term effect of multilevel surgery on adipokines and pro-inflammatory cytokines in patients with obstructive sleep apnea.[J].2010,130(12).
- [13]Ryan F,Butt A,Mulgrew A,etc.Pro-atherogenic cytokine profile of patients with suspected obstructive sleep apnea.[J].2009,13(4).
- [14]Djiane J,Laud K,Gourdou I,etc.Identification of leptin receptors in human breast cancer: functional activity in the T47-D breast cancer cell line.[J].2002,188(1).