Abstract： Objective To explore the effects of psychological nursing intervention on the negative emotion and sexual function in patients with hysteromyoma.Methods Eighty patients with hysteromyoma were divided into the observation group and the control group,the control group was given routine nursing,the observation group adopted psychological nursing intervention on the basis of routine nursing,two groups were compared with negative emotion and sexual function after 6 months.Results The improvement degree of depression and sexual funciton in the observation group both were better than those in control group (P＜0.05).Condusions Psychological nursing intervention is beneficial to improve the negative psychology and the postoperative sexual function in patients with hysteromyoma.