Abstract： Objective To explore the impact of nursing intervention on clinical outcomes in children with severe heavy hand,foot and mouth disease,provide the basis for the enactment of the child care program for severe heavy hand,foot and mouth disease.Methods A total of 104 children with severe heavy hand,foot and mouth disease in our hospital pediatric hospitalization January 1,2010 to July 2011 were divided into the observation group with 56 cases,the control group with 48 cases.The observation group implemented nursing intervention.The control group adopted routine pediatric care.The major symptoms disappearance time,hospitalization time,morbidity and mortality of two groups were observed.Results Hospitalization time and the major symptoms disappearance time of the observation group were significantly less than those of the control group,P ＜ 0.01 ; The number of patients transferred to 1CU of the observation group was significantly less than that of the control group,P ＜ 0.01.Conclusions Strengthening nursing interventions can effectively promote the rehabilitation of patients with severe heavy hand,foot and mouth disease,reduce the incidence of serious complications and death.