Abstract： Objective To explore the clinical efficacy of the humanistic nursing management that was implemented by the nurses who was in the psychiatry open ward. Methods There were 120 patients hospitalized patients with schizophrenia who were tested objects in hospital from March to December, 2009. According to the length of stays, they were devided into study group and contral group. There was 60 patients in each gruoup. Two groups were on the basis of system treatment of the antipsychotic drug, the contral group was accepted the ward conventional nursing management, the study group was accepted the humanistic nursing management. When they left the hospital, the clinincal effects were evaluated by the psychological comfort questionnaire , SCL-90, NOSIE and the hospital patient satisfaction questionnaire for both groups. Results When they left the hospital, the feeling of safety in study group was 86. 7%, satisfaction was 95.6%, feeling respect was 92. 5%. The feeling of safety in contral group was 45.6%, satisfaction was 57.8%, feeling respect was 41.3%. There were significant differences between two groups (x2 respectively was 49. 6 , 36. 5 and 23.2, P ＜ 0. 01 ). The total score of SCL - 90 in the study group was ( 1.45 ± 0. 73), it was ( 1.76 ± 0. 52) in the concral group, there was significant differences between two groups ( t = 2. 68, P ＜0. 01 ). Two groups of behavioral problems were comparied, the illness total score estimates of NOSIE in the study group was (186. 79 ±9. 84), in the contral group it was ( 165. 12 ±9. 21 ), there were sigpificant differences between two groups (t = 13. 10, P ＜0.01 ). The overall satisfaction in the study group was (4. 87 ±0. 77), in the contral group it was (4. 32 ± 0. 54), there was significant differences between two groups ( t = 4. 53, P ＜ 0. 01 ) . Conclusions Implementing humanistic nursing management, and providing the high quality nursing service could enhance psychiatric hospital patient satisfaction, and promote schizophrenia patients with mental and behavioural disorders,it would have significant positive effects for the overall recovery of schizophrenia patients.