Abstract： Objective Low -temperature + UF curves HD, sodium curve + UF curves HD, low -temperature + sodium curve HD, low - temperature + sodium curve HD + UF curves HD, HD + oral administration of midodrine before dialysis' and conventional HD were comprised to observe hypotension occurrence during hemodialysis. Methods Twenty patients were selected who occurred related hypotension frequently. They were treated with the following proposals: conventional HD, low -temperature + UF curves HD, sodium ctuve+UF curves HD, low - temperature + sodium curve HD, low - temperature + sodium curve + UF curves HD, conventional HD + oral administration of midodrine before dialysis. Each patient's treatments lasted four weeks under each dialysis mode. The incidence of hypotension were observed and compared among six dialysis modes. Results The incidence of hypotension in low - temperature + UF curves, sodium curve + UF curves, low - temperature + sodium curve groups were lower than that of ( P ＜ 0. 05), the incidence of hypotension in lowtemperature + sodium curve + UF curves, oral administration of midodrine before dialysis groups were significant lower than that of conventional group (P＜0.01) . The incidences of hypotension among low- temperature + UF curves HD group, sodium curve + UF curves group and low - temperature + sodium curve group were no difference ( P ＞ 0. 05) . The incidences of hypotension between low - temperature + sodium curve + UF curves group and oral administration of midodrine group were no difference ( P ＞ 0. 05) . There was significant difference by statistical treatment on incidences of hypotension between low - temperature + UF curves group, sodium curve + UF curves group, low- temperature + sodium curve group and low- temperature + sodium curve + UF curves group, conventional HD + oral administration of midodrine before dialysis group (P＜0.01). Conclusions The incidences of hypotension in low - temperature + sodium curve + UF curves group and conventional HD + oral administration of midodrine before dialysis group were no statistical significance ( P＜0. 01). It hints that the effect of preventing dialysis - related hypotension is the best under two modes. The patients can choose these modes according to their economy and endurance.