Abstract： Objective To observe the clinical effect of subcutaneous tunnel of femoral vein puncture used for patients with severe craniocerebral trauma to reduce related infection and complications caused by the canal.Methods A total of 139 unconscious severe craniocerebral injured patients were divided into two groups in random: observation group ( n = 70) and control group ( n =69) .The patients in observation group were set up a vein routeway through subcutaneous tunnel of femoral vein puncture, while patients in the control group were set up a vein routeway through tradition-al femoral vein puncture.The complications of canal shedding, related infection and the puncture place infection and the time of retuning the canal were observed.Results The retaining canal time of observation group was longer than that of the control group, and the puncture place infection of the observation group was less than that of the control group.The difference was very remarkable (P ＜ 0.05 or P ＜ 0.01 ).But the occurrence rate of canal blocking of the two groups had no difference ( P ＞ 0.05 )Conclusions The occurrence rate of syndrome of canal especially canal related infection can be reduced and the retaining canal time can be extended by means of setting up vein routeway through subcutaneous tunnel of femoral vein puncture plus prophylactic nursing intervention.The method can be applied to the patients in need of long-term keeping transfusing passage.