Abstract： Objective To study clinical effects of fundus fluoreseein angiography (FFA) combined with indocyanine green angiography (ICGA) compared to traditional separated exam.Methods Thirty patients in experiment group were undergone FFA combined with ICGA exams.The other 30 patients in tradition group were undergone ICGA exams a day after FFA exams by random.Complications of both groups were obsereved and studied.Results (1) One patient with nausea and vomit in experiment group was compared to one patient with nausea when FFA exam and one patient with nausea when ICGA exam in tradition group.There was no significant difference (P ＞ 0.05) in digestive complications between two groups.(2) There was no significant difference (P ＞0.05) in blood pressure,heart rate,blood oxygen saturation coefficient when exam between two groups.Conclusios FFA combined with ICGA is a safe and effective exam method.