Abstract： Objective To investigate the safety by using fast track surgery (FTS) pattern in the perioperative period for 40 colorectal cancer patients. Methods 75 colorectal cancer patients were divided into two groups randomly, 40 in FTS pattern (FTS group) and 35 in traditional pattern (traditional group), Analysis and research on the detection of serological indicator before and after operation, the first exhaust time after operation, hospital stays, hospitalization expenses and incidence rate of complications. Replenishment quantity was controlled to be 1 500 ～ 2 000 ml strictly everyday after operation, 2 ～ 3 days to stop transfusion. FTS group was given food early and relieved pain fully after operation. Controlled analgesia pump was used for FTS group, and the nursing methods was changed, accordingly Perioperatire nursing methods were improved to adapt the FTS nursing measure continuously. Results Compared with those in traditional group, the fasting blood-glucose and insulin resistance levels of FTS group were greatly lower after operation ( P ＜ 0. 05 ) . The first exhaust time,weight loss, hospital stays and hospitalization expenses were greatly reduced after operation. Conclusions FPS pattern is safe and effective,hyperglycemia can be controlled effectively for FTS group, it can reduce hospital stays and hospitalization expenses. No complication or adverse reaction was occurred among the FTS group in the perioperative period. FTS pattern is useful way for nurse to serve the patients.