Abstract: AngiotensinⅡ (AngⅡ) has growth factor and cytokine -like properties. It plays an important role in the development of atherosclerosis (AS). The effects of promoting migration, proliferation, apoptosis, phenotype translation and promoting the secretion and expression of many kinds of pro - inflammatory cytokines, growth factors and extracellular matrix proteins to vascular smooth muscle cells (VSMCs) in the progress of AS are reviewed in this article.