Abstract: It introduced the clinical characteristics and nursing of acute coronary syndrome. It expatiated the research progress on first aid and nursing of coronary syndrome patients from aspects of quickly evaluation, fight away treatment, and effective intervention on high risk acute coronary syndrome patients, paying attention to observe atypical symptoms of them, complication prevention, observation on drug efficacy and adverse reaction, nursing of thrombolysis therapy and coronary artery intervention therapy, the chain of first aid and nursing about pre -hospital -hospital -CCU, health education.