Abstract: Mild hypothermia in the clinical application was received scrutiny, and applied in the gradual broadening, the treatment means became more diverse. In recent years, it was used for the treatment of neonates with hypoxic encephalopathy, cerebral protection cardio -pulmonary resuscitation, brain injury and stroke and other fields. Clinical application of the current included ice cooling method, medical ice blanket cooling method, selective head cooling, whole body mild hypothermia therapy. The cooling effect of these methods were different, there were many drawbacks, and some methods were still in the experimental stage.