Abstract: Objective To research the effect of nursing intervention for climacteric women in depression status. Methods 80 depressed climacteric women were randomly divided into control and observation groups. The observation group was given integration nursing intervention. The Self-rating Depressive Scale (SDS), Symptom Checklist 90 (SCL-90), Social Support Bating Scale (SSBS) were used to evaluate the treatment effective-hess. Results Before nursing intervention, the scores of SDS, SSRS, SCL-90 between two groups werenot dif-ferent;and the scores of SDS, SSRS, SCL - 90 were significant difference after the nursing intervention (P <0.01 ). Conclusions The treatment with nursing intervention can improve the depressive state of patients, uplift patients'life quality, lighten the burden of society and patients'familles, and embody the idea of people oriented.