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The expression and clinical significance of the serum IL-17/LTB4/IgE in children with asthma

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Author:
No author available
Journal Title:
International Journal of Pediatrics
Issue:
4
DOI:
10.3760/cma.j.issn.1673-4408.2012.04.031
Key Word:
哮喘;白细胞介素17;白三烯B4;IgE;中性粒细胞;儿童;Asthma;Interleukine-17;Leukotriene B4;IgE;Polymorphonuclear neutrophils;Children

Abstract: Objective To explore the impact of levels of serum IL-17,Leukotriene B4 and IgE on pathogenesis of childhood asthma.Methods Totally 60 children with asthma acute exacerbation ( 29 children with mild asthma,31 children with moderate-severe asthma) were selected as study group,24 healthy children were selected as control group.Serum IL-17 and LTB4 were measured with euryzemLinked immunosorbent assay,serum IgE was determined with enzyme-linked fluoroimmuneassay by pharmacia CAP Sytem,PMN was determined with automatic blood analyser,pulmonary function was measured in the study group.Results ( 1 ) The level of serum IL-17 ( 1.15 ± 0.10 μg/L,2.80 ± 2.30 μg/L,0.83 ± 0.10 μg/L),LTB4 (2.22 ± 1.01 μg/L,8.79 ± 9.36 μg/L,1.94 ± 1.13 μg/L) and IgE( 123.70 ±86.94 μg/L,322.27 ±332.28 μg/L,24.27 ±7.64 μg/L) were significantly different among mild asthma group,moderate-severe asthma group and control group( P < 0.001 ).( 2 )The N% of mild asthma group,moderate-severe asthma group and study group were( 55.06 ± 1 1.15 ) %,( 64.44± 11.87)%,(47.96 ± 13.52)%,L% were(42.20 ± 11.04)%,(33.93 ± 10.02)%,(49.65 ± 13.02)%,and there were significant differences in N% and L% between study group and control group( P < 0.05 ).( 3 ) There were significant positive correlations between the serum IL-17 levels and IgE,LTB4 and IgE,IL-17 and LTB4 in asthmatic children( P <0.05).(4) There were significant negative correlcations between the level of serum IL-17,LTB4 and FEVI,PEF( P <0.001 ).There were significant positive correlations between serum IL-17,LTB4 and N% (P <0.001 ).(5)There were not correlations between the level of serum IgE and FEV1,PEF and N%in asthmatic children( P >0.05 ).Conclusion The levels of serum IL-17,LTB4 and IgE participated in pathogenesis on asthmatic children patients.

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