Abstract: Pediatric venous thromboembolism is a life-threatening disease caused by many factors,of which the central venous catheter is the first high-risk factor,and the clinical presentation varies according to the position of obstruction.Color Doppler ultrasound,CT scan,MRI are the major diagnostic techniques.Low-molecular-weight heparin combines with oral anticoagulant agent are commonly used in therapy and prophylaxis.Early diagnosis and prevention are beneficial to the survival rate.