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Progress in gene polymorphism associated with the severity of children asthma

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Author:: No author available

Journal Title:: International Journal of Pediatrics

Issue:: 4

DOI:: 10.3760/cma.j.issn.1673-4408.2012.04.011

Key Word:: 哮喘;基因多态性;儿童;严重度;Asthma;Gene polymorphism;Childhood;Severity

Abstract： Most childhood asthma is easily controlled with regular use of inhaled corticosteroid (ICS)and rescue bronchodilators.However,despite effective therapies,there are many children with severe asthma who do not achieve well control.Those proportion of children will have persisting symptoms,frequent exacerbations and frequent hospitalization/emergency department visits.The reasons are complex and diverse.Although treatment compliance is a very important factor,about 70％ of the variability is determined by genes.Many gene polymorphisms have been identified to be associated with asthma,such as susceptibility,airflow obstructuin,airways responsiveness and treatment response.To improve the treatment and the quality of life,and achieve the individualized targeted therapy matched with the severity of disease,it is important to identify the relationship between gene polymorphism and the severity of children asthma.

Reference

[1]金蕊.哮喘易感基因的研究进展[J].2011,(3).
[2]Carroll CL,Schramm CM,Zucker AR,etc.Beta2-adrenergic receptor polymorphisms affect response to treatment in children with severe asthma exacerbations.[J].2009,135(5).
[3]Moffatt MF,Demenais F,Heath S,etc.A large-scale, consortium-based genomewide association study of asthma.[J].2010,363(13).
[4]Royce SG,Tang ML,Stewart AG,etc.Airway remodelling in asthma: current understanding and implications for future therapies.[J].2006,112(2).
[5]Belessis Y,Thomsen A,Morton J,etc.Risk factors for an intensive care unit admission in children with asthma.[J].2004,37(3).
[6]Shin YJ,Kwon JW,Kim BJ,etc.Polymorphisms of the PTGDR and LTC4S influence responsiveness to leukotriene receptor antagonists in Korean children with asthma.[J].2011,56(4).
[7]Panek, Michal,Pietras, Tadeusz,Antczak, Adam,etc.The role of functional single nucleotide polymorphisms of the human glucocorticoid receptor gene NR3C1 in Polish patients with bronchial asthma[J].2012,39(4).
[8]Vijverberg SJ,Raaijmakers JA,Palmer CN,etc.FCER2 T2206C variant associated with chronic symptoms and exacerbations in steroid-treated asthmatic children.[J].2011,66(12).
[9]Patricia J. LYELL,Elmer VILLANUEVA,Debbie BURTON,etc.Risk factors for intensive care in children with acute asthma[J].2005,10(4).
[10]Paul, Van Eerdewegh,Randall D, Little,Josée, Dupuis,etc.Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness.[J].2002,418(6896).
[11]E, Bouzigon,V, Siroux,M-H, Dizier,etc.Scores of asthma and asthma severity reveal new regions of linkage in EGEA study families.[J].2007,30(2).
[12]Walther JL,Minguez MM,Hermosa JL,etc.Factors associated with the control of severe asthma.[J].2010,47(2).
[13]Bush A,Rogers AV,Bandi V,etc.Early thickening of the reticular basement membrane in children with difficult asthma.[J].2003,167(1).
[14]Lange LA,Postma DS,Ampleford EJ,etc.Estrogen receptor 1 polymorphisms are associated with airway hyperresponsiveness and lung function decline, particularly in female subjects with asthma.[J].2006,117(3).
[15]Olivenstein R,Lemiere C,Pepe C,etc.Differences in airway remodeling between subjects with severe and moderate asthma.[J].2005,116(3).
[16]Taylor DR,Town GI,Herbison GP,etc.Asthma exacerbations during long term beta agonist use: influence of beta(2) adrenoceptor polymorphism.[J].2000,55(9).
[17]Lee,C.G.,Ma,B.,Takyar,S.,etc.Studies of vascular endothelial growth factor in asthma and chronic obstructive pulmonary disease[J].2011,8(6).
[18]Rebordosa,C.,Kogevinas,M.,Guerra,S.,etc.ADRB2 Gly16Arg polymorphism, asthma control and lung function decline[J].2011,38(5).
[19]Hizawa N.Pharmacogenetics of beta2-agonists.[J].2011,60(3).
[20]Taka-Aki, Nakada,James A, Russell,John H, Boyd,etc.beta2-Adrenergic receptor gene polymorphism is associated with mortality in septic shock.[J].2010,181(2).
[21]Meng, Q.,An, Y.,Fang, C.,etc.T-helper cell type 2 (Th2) memory T cell-potentiating cytokine IL-25 has the potential to promote angiogenesis in asthma[J].2011,108(4).
[22]H, Jongepier,H M, Boezen,A, Dijkstra,etc.Polymorphisms of the ADAM33 gene are associated with accelerated lung function decline in asthma.[J].2004,34(5).
[23]Zhang G,Khoo SK,Bizzintino JA.Leukotriene pathway polymorphisms are associated with altered cysteinyl leukotriene production in children with acute asthma.[J].2009,81(1).
[24]Silverman EK,Casal J,Castro RA,etc.Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthma.[J].2005,171(6).
[25]Detoraki A,Granata F,Staibano S,etc.Angiogenesis and lymphangiogenesis in bronchial asthma.[J].2010,65(8).
[26]van Diemen CC,Boezen HM,Bruinenberg M,etc.A disintegrin and metalloprotease 33 polymorphisms and lung function decline in the general population.[J].2005,172(3).
[27]Mariani TJ,Lazarus R,Weiss ST,etc.FCER2: a pharmacogenetic basis for severe exacerbations in children with asthma.[J].2007,120(6).
[28]Murphy AJ,Soto Quiros ME,Sylvia JS,etc.Association of VEGF polymorphisms with childhood asthma, lung function and airway responsiveness.[J].2009,33(6).