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Advancement of Th17 cells in bronchopulmonary dysplasia

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Author:: No author available

Journal Title:: International Journal of Pediatrics

Issue:: 4

DOI:: 10.3760/cma.j.issn.1673-4408.2012.04.006

Key Word:: Th17;IL-17;支气管肺发育不良;Th17;Interleukin-17;Bronchopulmonary dysplasia

Abstract： T helper 17 cells(Th17) are a recently discovered CD4+ T cells subsets,a new member of the Th1,Th2 family.Recent studies have found that IL-17 produced by Th17 can induce bronchial epithelial cells,endothelial cells and fibroblasts secreting IL-6,IL-8,ranulocyte colony-stimulating factor and tumor necrosis factor alpha and other cytokines,and promot recruitment of neutrophils in lung.Present studies show that th17plays an important role in the bronchopulmonary dysplasia incidence mechanism,and provides a new research direction in the prevention and treatment.

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