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Progress of prenatal infection and preterm bronchopulmonary dysplasia

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Author:: No author available

Journal Title:: International Journal of Pediatrics

Issue:: 4

DOI:: 10.3760/cma.j.issn.1673-4408.2012.04.004

Key Word:: 产前感染;炎症;细胞因子;早产儿;支气管肺发育不良;Intra-uterine infection;Inflammation;Cytokines;Preterm;Bronchopulmonary dysplasia

Abstract： In recent years a body of data has accumulated,linking preterm bronchopulmonary dysplasia (BPD) to prenatal infections and inflammations.The lungs of preterms are still in development.Fetal lungs with intrauterine infections are exposed to high levels of inflammation factors ahead of time,which does harms to lungs.The immune systems of preterms are so immature that they can not effectively down-regulate and control the inflammation process,which exaggerates the inflammation process and causes the abnormal levels of some important growth factors during lung development.As a result,the lung undergoes an dysmorphic microvasculature and disrupted alveolarization,which leads to BPD eventually because of the stagnancy of lung developing.

Reference

[1]张慧,富建华,薛辛东.机械通气早产儿支气管肺发育不良的高危因素分析[J].2011,(3).
[2]丁璐,吴本清.早产儿支气管肺发育不良的病因及发病机制新进展[J].2008,(6).
[3]Yasumatsu R,Weber E,Bingol Karakoc G,etc.Imbalance between Cysteine Proteases and Inhibitors in a Baboon Model of Bronchopulmonary Dysplasia.[J].2006,173(3).
[4]Wirbelauer J,Speer CP.The role of surfactant treatment in preterm infants and term newborns with acute respiratory distress syndrome.[J].2009,29(Suppl.2).
[5]Anna-Karin Husa,Reetta Vuolteenaho,Reija Paananen.Blood Cytokines during the Perinatal Period in Very Preterm Infants: Relationship of Inflammatory Response and Bronchopulmonary Dysplasia[J].2009,154(1).
[6]Kunzmann, Steffen,Speer, Christian P.,Jobe, Alan H.,etc.Antenatal inflammation induced TGF-β1 but suppressed CTGF in preterm lungs.[J].2007,36(1).
[7]Lu CH,Shi TT,Tarantal AF,etc.Overexpression of transforming growth factor-beta1 in fetal monkey lung results in prenatal pulmonary fibrosis.[J].2010,36(4).
[8]Carlton DP,Palta M,Sadek Badawi M.Association of BPD and IVH with early neutrophil and white counts in VLBW neonates with gestational age <32 weeks.[J].2008,28(9).
[9]Heck DE,Vasquez P,Laskin DL,etc.Mechanisms underlying reduced apoptosis in neonatal neutrophils.[J].2005,57(1).
[10]Bernard, Thébaud,Faruqa, Ladha,Evangelos D, Michelakis,etc.Vascular endothelial growth factor gene therapy increases survival, promotes lung angiogenesis, and prevents alveolar damage in hyperoxia-induced lung injury: evidence that angiogenesis participates in alveolarization.[J].2005,112(16).
[11]Waxman A,Chetty A,Manzo N,etc.The role of IL-6 and IL-11 in hyperoxic injury in developing lung.[J].2008,43(3).
[12]刘冬云,吴静,张小英,等.支气管肺发育不良新生儿支气管肺泡灌洗液IL-8 SP-A和TGF-β1的表达[J].2010,(6).
[13]Speer CP.Inflammation and bronchopulmonary dysplasia: a continuing story.[J].2006,11(5).
[14]Katz B,Waites KB,Benjamin DK Jr,etc.Critical appraisal of the role of Ureaplasma in the development of bronchopulmonary dysplasia with metaanalytic techniques.[J].2005,24(12).
[15]Kramer, Elizabeth L.,Deutsch, Gail H.,Sartor, Maureen A.,etc.Perinatal increases in TGF-α disrupt the saccular phase of lung morphogenesis and cause remodeling: microarray analysis.[J].2007,37(2).
[16]Hodge R,Miralles R,Grant WD,etc.Pulmonary Ureaplasma urealyticum is associated with the development of acute lung inflammation and chronic lung disease in preterm infants.[J].2004,55(1).
[17]Ballabh P,Shin JJ,Auld PA,etc.Soluble E-selectin, soluble L-selectin and soluble ICAM-1 in bronchopulmonary dysplasia, and changes with dexamethasone.[J].2003,111(3).
[18]Murphy S,Watterberg KL,Demers LM,etc.Chorioamnionitis and early lung inflammation in infants in whom bronchopulmonary dysplasia develops.[J].1996,97(2).
[19]Marx A,Kramer BW,Speer CP,etc.Airway concentrations of angiopoietin-1 and endostatin in ventilated extremely premature infants are decreased after funisitis and unbalanced with bronchopulmonary dysplasia/death.[J].2009,65(4).
[20]Turunen R,Andersson S,Repo H,etc.Onset of mechanical ventilation is associated with rapid activation of circulating phagocytes in preterm infants.[J].2006,117(2).
[21]De-Dooy J,Stevens W,De-Clerck L,etc.High levels of CXCL8 in tracheal aspirate samples taken at birth are associated with adverse respiratory outcome only in preterm infants younger than 28 weeks gestation.[J].2007,42(3).
[22]Reiss I,Ruhlmann A,Ghofrani HA,etc.Inhibition of phosphodiesterase 4 enhances lung alveolarisation in neonatal mice exposed to hyperoxia.[J].2009,33(4).
[23]Chang L,Twomey A,Cuttitta F,etc.Bombesin-like peptides modulate alveolarization and angiogenesis in bronchopulmonary dysplasia.[J].2007,176(9).
[24]Bry K,Whitsett JA,Lappalainen U.IL-1beta disrupts postnatal lung morphogenesis in the mouse.[J].2007,36(1).
[25]Bancalari E,Claure N,Young KC,etc.The association between early tracheal colonization and bronchopulmonary dysplasia.[J].2005,25(6).
[26]Marx A,Thomas W,Chmielnicka Kopaczyk M,etc.Clara cell secretory protein in tracheobronchial aspirates and umbilical cord serum of extremely premature infants with systemic inflammation.[J].2010,97(3).