You Position: Home > Paper
Analysis of infection-related mortality after allogeneic hematopoietic stem cell transplantation in patients with refractory/relapse acute leukemia
( views:395, downloads:57 )
- Author:
- No author available
- Journal Title:
- Journal of Southern Medical University
- Issue:
- 9
- DOI:
- 10.3969/j.issn.1673-4254.2012.09.038
- Key Word:
- 难治复发急性白血病;造血干细胞移植;感染相关死亡
Abstract： 目的 探讨难治复发急性白血病患者接受异基因造血干细胞移植(allo-HSCT)后感染相关死亡(IRM)的特点.方法 回顾分析127例接受allo-HSCT的难治复发急性白血病患者的临床资料,统计感染相关死亡情况并分析危险因素.结果 观察期内67例死亡.5年总生存率为(35.2±5.3)％,无病生存率为(30.8±5.6)％.28.3％ (36/127)患者发生感染相关死亡.Ⅱ～Ⅳ°aGVHD (P=0.049,OR=3.017)和移植后IFI(P=0.032,OR=3.223)是IRM的独立危险因素.结论 感染作为移植相关死亡的主要原因,相对于标危患者,在难治复发患者中占更高的比例.更多的关注严重GVHD后感染的预防和治疗力度是目前减少IRM的主要措施.
- [1].关于难治性急性白血病诊断标准的商讨纪要[J].2004,(2).
- [2]刘启发,孙竞,徐丹,等.难治性白血病异基因造血干细胞移植超强预处理的疗效[J].2004,(10).
- [3]孙竞,孟凡义,刘启发,等.诱导aGVHD策略的异基因造血干细胞移植治疗难治复发性急性白血病的初步临床报告[J].2003,(12).
- [4]中国侵袭性真菌感染工作组.血液病/恶性肿瘤患者侵袭性真菌感染的诊断标准与治疗原则（第三次修订）[J].2010,(5).
- [5]王昱,刘开彦,许兰平,等.异基因造血干细胞移植治疗高危恶性血液病[J].2007,(11).
- [6]Einsele H,Reusser P,Brand R,etc.Cause of death after allogeneic haematopoietic stem cell transplantation (HSCT) in early leukaemias: an EBMT analysis of lethal infectious complications and changes over calendar time.[J].2005,36(9).
- [7]Miller JS,Defor T,Bachanova V,etc.Fewer infections and lower infection-related mortality following non-myeloablative versus myeloablative conditioning for allotransplantation of patients with lymphoma.[J].2009,43(3).
- [8]Cavazzana-Cavo M,Bourhis JH,Rio B,etc.Long-term outcome after allogeneic hematopoietic stem cell transplantation for advanced stage acute myeloblastic leukemia: a retrospective study of 379 patients reported to the Societe Francaise de Greffe de Moelle (SFGM).[J].2000,26(11).
- [9]Wingard JR,Hsu J,Hiemenz JW.Hematopoietic stem cell transplantation: an overview of infection risks and epidemiology.[J].2011,25(1).
- [10]Aschan J,Winiarski J,Bjorklund A,etc.Risk factors for fatal infectious complications developing late after allogeneic stem cell transplantation.[J].2007,40(11).
- [11]Gafter Gvili A,Yahav D,Muchtar.Antiviral prophylaxis in haematological patients: systematic review and meta-analysis.[J].2009,45(18).
- [12]Tomblyn M,Chiller T,Einsele H.Guidelines for preventing infectious complications among hematopoietic cell transplantation recipients: a global perspective.[J].2009,15(10).
- [13]K W, Song,J, Lipton.Is it appropriate to offer allogeneic hematopoietic stem cell transplantation to patients with primary refractory acute myeloid leukemia?[J].2005,36(3).
- [14]Miguel Cisneros J,Parody R,Martin Pena A,etc.Prospective study of infectious complications in allogeneic hematopoietic stem cell transplant recipients.[J].2011,25(3).
- [15]Sierra J,Martino R,Kerguelen A,etc.Reduction of infection-related mortality after allogeneic PBSCT from HLA-identical siblings: longitudinal analysis from 1994 to 2008 at a single institution.[J].2011,46(5).
- [16]Gutierrez-Aguirre CH,Morales-Toquero A,Salazar-Riojas R,etc.Non-myeloablative hematopoietic stem cell transplantation is of limited value in advanced or refractory acute myeloblastic leukemia. The Mexican experience.[J].2007,12(3).
- [17]赵孟霞,孙竞,范志平,等.氟康唑与伊曲康唑预防造血干细胞移植真菌感染的效果[J].2010,(9).