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Protocadherin α gene cluster is required for myelination and oligodendrocyte development
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- Author:
- No author available
- Journal Title:
- Zoological Research
- Issue:
- 4
- DOI:
- 10.3724/SP.J.1141.2012.04362
- Key Word:
- 原钙黏蛋白;髓鞘;少突胶质细胞;发育
Abstract： 该文通过免疫组化及蛋白免疫印迹的方法分别对Pcdhα基因敲除和对照组小鼠的中枢神经系统内的髓鞘碱性蛋白表达以及少突胶质细胞的发育进行了测定.结果表明:1)Pcdhα基因缺失小鼠中枢神经系统中的髓鞘碱性蛋白较对照组小鼠明显减少;2)Pcdhα基因敲除可导致少突胶质细胞发育异常:在小脑中,处于成熟期的少突胶质细胞减少,而处于前体细胞阶段的少突胶质细胞增多.上述结果提示Pcdhα可以通过调控少突胶质细胞的成熟过程进而影响髓鞘的形成.
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