Abstract： AIM:To investigate the correlation between glucagon like peptides-1(GLP-1)and inflammatory cytokines and evaluate mechanism of diabetic cardiomyopathy.METHODS:Serum GLP-1,hyper sensitive C-reactive protein(hs-CRP),interleukin6(IL-6),tumor necrosis factor-α(TNF-α),blood pressure,fasting plasma glucose,2 h plasma glucose(2hPG),fasting serum insulin(FINS)and homeostasis model assessment insulin resistance(HOMA-IR)were measured in 50 patients with diabetic cardiomyopathy(experimental group)and 30 healthy persons(control group).RESULTS:Compared with control group,fasting plasma glucose,2hPG,systolic pressure,FINS,HOMA-IR,hs-CRP,IL-6 and TNF-α were significantly increased(P<0.05),while serum GLP-1 were reduced in experimental group(P<0.05);serum GLP-1 were negatively correlated with hs-CRP(r=0.556,P=0.1302)and HOMA-IR(r=0.445,P=0.007).CONCLUSION:The occurance and development of diabetic cardiomyopathy is decided by interrelation of GLP-1,inflammatory cytokines and insulin resistance.