Abstract： AIM:To observe the expression of vascular endothelial growth factor, tumor necrosis factorα(TNF-α), vascular endothelial growth factor receptor-proteinum 1, vascular endotbeiial growth factor receptor-proteinum 2 ,tumor necrosis factor-α receptor-proteinum 5500 kD(P55)and tumor necrosis factor-α receptor-proteinum 7500 kD(P75)in nasopharyngeal carcinoma, and analyze dependability of those cell factor. METHODS:Sixty tissues of nasopharyngeal carcinoma were stained with immunizing histological chemistry way, expression of VEGF, TNF-α, VEGFRI, VEGFR2, P55, P75 were measured, and analysize the dependability. RESULTS:VEGF, TNF-α, VEGFR1, VEGFR2,P55 and P75 were expressed in tissues of nasopharyngeal carcinoma, there were positive dependability between VEGF and VEGFRI ,VEGF and VEGFR2, TNF-α and P55(r =0.442, P=0.002), VEGF and TNF-α. CONCLUSION:TNF-α, P55 and P75 had an over expression in tissues of nasopharyngeal carcinoma.VEGF and TNF-α maybe nasopharyngeal carcinoma to nasopharyngeal carcinoma by mutual control to receptor protein.