Immunohistochemic expression of DACH1 and its clinical significance in papillary thyroid carcinoma

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Author:
ZHAO Xin(Xijing Hospital, Fourth Military Medical University)
ZHOU Jie(Xijing Hospital, Fourth Military Medical University)
SI Cui(Xijing Hospital, Fourth Military Medical University)
WANG Wen-Yong(Fourth Military Medical University)
ZHANG Nan-Yan(Xijing Hospital, Fourth Military Medical University)
WANG Chen-Guang(Thomas Jefferson University)
JI Qiu-He(Xijing Hospital, Fourth Military Medical University)
Journal Title:
JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY
Issue:
Volume 30, Issue 24, 2009
DOI:
Key Word:
DACH1; papillary thyroid carcinoma; immunohistochemistry

Abstract´╝Ü AIM:To explore the immunohistochemical expression of DACH1 in papillary thyroid carcinoma and its clinical significance. METHODS:DACH1 expression in 10 nodular goiters, and 30 papillary thyroid carcinomas were detected with SABC immunohistochemical method, and the relationship between DACH1 expression and clinicopathological characteristics were further analyzed. RESULTS:The immunohistochemic expression of DACHl in papillary thyroid carcinoma and goiter is orientated as the cytomembrane and cytoplasm. The positive rate of DACH1 is 76.7% in papillary thyroid carcinoma, notably higher than that in nodular goiter, later is 30%(P<0.01). The positive rate of expression of DACH1 protein in papillary thyroid carcinoma with lymph nodes metastasis was 89. 5%, while it was 54. 5% in group of without lymph nodes metastasis. The differences are significant(P<0.05). CONCLUSION:The DACH1 protein is immunohistochemic overpressed in papillary thyroid carcinoma.There is obvious relationship between the degree of infiltration and metastasis of lymph node, indicating that DACHI may play a role in the carcinogenesis and development of papillary thyroid carcinoma.

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