Immunohistochemic expression of DACH1 and its clinical significance in papillary thyroid carcinoma

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ZHAO Xin(Xijing Hospital, Fourth Military Medical University)
ZHOU Jie(Xijing Hospital, Fourth Military Medical University)
SI Cui(Xijing Hospital, Fourth Military Medical University)
WANG Wen-Yong(Fourth Military Medical University)
ZHANG Nan-Yan(Xijing Hospital, Fourth Military Medical University)
WANG Chen-Guang(Thomas Jefferson University)
JI Qiu-He(Xijing Hospital, Fourth Military Medical University)
Journal Title:
Volume 30, Issue 24, 2009
Key Word:
DACH1; papillary thyroid carcinoma; immunohistochemistry

Abstract´╝Ü AIM:To explore the immunohistochemical expression of DACH1 in papillary thyroid carcinoma and its clinical significance. METHODS:DACH1 expression in 10 nodular goiters, and 30 papillary thyroid carcinomas were detected with SABC immunohistochemical method, and the relationship between DACH1 expression and clinicopathological characteristics were further analyzed. RESULTS:The immunohistochemic expression of DACHl in papillary thyroid carcinoma and goiter is orientated as the cytomembrane and cytoplasm. The positive rate of DACH1 is 76.7% in papillary thyroid carcinoma, notably higher than that in nodular goiter, later is 30%(P<0.01). The positive rate of expression of DACH1 protein in papillary thyroid carcinoma with lymph nodes metastasis was 89. 5%, while it was 54. 5% in group of without lymph nodes metastasis. The differences are significant(P<0.05). CONCLUSION:The DACH1 protein is immunohistochemic overpressed in papillary thyroid carcinoma.There is obvious relationship between the degree of infiltration and metastasis of lymph node, indicating that DACHI may play a role in the carcinogenesis and development of papillary thyroid carcinoma.

  • [1]Wu K,Liu M,Li A,et al.Cell fate determination factor DAHC1 inhibits c-jun-induced contact-independent srowth[J].Mol Cell Biol,2007,18(3):755-767.
  • [2]Heanue TA,Davis RJ,Rowiteh DH,et al.DACHI,a vertebrate homologue of Drosophila dachshund,is expressed in the developing eye and ear of both chick and mouse and is regulated independently of Pax and Eya genes[J].Mech Dev,2002,111(1-2):75-87.
  • [3]Wu K,Katiyar S,Li A,et al.Dachshund inhibits oncogene-induced breast cancer cellular migration and invasion through suppression of intedeukin-8[J].Proc Natl Acad Sci USA,2008,180(3):1126-1130.
  • [4]Wu K,Li A,Rao al.DACHl is a cellfate determinationfactor that inhibits cyclin D1 and breast tumor growth[J].Mol Cell Biol,2006,26(19):7116-7129.
  • [5]Mai KT,Landry DC,Thomas J,et al.Ret oncongene protein expression in papillary thyroid carcinoma and related lesions[J].Tumori,2001,87:166-172.
  • [6]Gimm O.Thyroid cancer[J].Cancer Lelt,2001,163:143-156.
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