Notch signal expression in the bone marrow of patients with acute promyelocytic leukemia

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Author:
ZHANG Li(Tangdu Hospital, Fourth Military Medical University)
XIA De-Yu(Tangdu Hospital, Fourth Military Medical University)
LI Guo-Hui(Tangdu Hospital, Fourth Military Medical University)
JIANG Shan-Shan(Tangdu Hospital, Fourth Military Medical University)
GU Fang-Na(Tangdu Hospital, Fourth Military Medical University)
HANG Ying-Min(Tangdu Hospital, Fourth Military Medical University)
Journal Title:
JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY
Issue:
Volume 30, Issue 24, 2009
DOI:
Key Word:
Notch ;acute promyelocytic leukemia

Abstract: AIM:To explore the possible role of Notch signaling in occurrence of acute promyelocytic leukemia(APL)through investigate the expression of Notch receptors, ligands and target gene in the bone marrow of patients with APL.METHODS:Semi-quantitative reverse transeriptase-polymerase chain reaction(RT-PCR)was used to investigate the expression of Notch1,Notch2,Notch3,Notch4,Delta-like-1,Delta-like-4,Jagged1,Hes1, Hes5 in the bone marrow of patients with APL,and the changes of expression after treatment.RESULTS:The expres-sions of Notch2, Jaggedl and Hesl were significantly lower after treatment, the expressions of the others have no significant difference. CONCLUSION:The changes of Notch2, Jagged1 and Hes1 expression after treatment are significant. The difference on the expression of Notch receptors and ligands may be important significance for the pathogenesis of APL.

  • [1]Artavanis-Tsakonas S,Rand M D,Lake RJ.Notch signaling:Cell fate control and signal integration in development[J].Science,1999,284(5415):770-776.
  • [2]达万明,裴涛.现代血液病学[M].北京:人民军医出版社,2003:780-786.
  • [3]Ellisen LW,Bird J,West DC,et al.The human homolog of the Drosophila Notch gene is broken by chromosomal translocafionsm T lymphobia.slit neoplasms[J].Cell,1991,66(4):649-661.
  • [4]Walker L,CarLson A,Tan-Pertel HT,et al.The notch receptor and its ligands are selectively expressed during hematopoietic development in the mouse.[J].Stem Cells,2001,19(6):543-552.
  • [5]Tohda S,Koqoshi H,Murakami N,et al.Diverse effects of the Notch ligands Jagged 1 and Delta 1 on the growth and differentiation of primary acute myeloblaatic leukemia cells[J].Exp Hematol,2005,33(5):558-563.
  • [6]Chiaramonte R,Basile A,Tassi E,et al.A wide role for NOTCHl signaling in acute leukemia[J].Cancer Lett,2005,219(1):113-120.
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