Effects of methoxychlor on bone loss (osteroporosis)in mice
- Author:
- No author available
- Journal Title:
- JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY
- Issue:
- 24
- DOI:
- 10.3321/j.issn:1000-2790.2009.24.036
- Key Word:
- 甲氧滴滴涕;骨质疏松;骨羟脯氨酸;骨钙;methoxychlor;osteoporosis;bone hydroxyproline;bone-calcium
Abstract： AIM:To investigate the effects of methoxychlor (MXC)on bone loss(osteroporosis)in mice. METHODS:MXC was administrated to the mice at doses of 0(control), 50,100 and 200mg/(kg·d)via oral gavage for consecutive 14d,then mice were euthanized. The thymus, liver and the spleen were weighted separately; then observed the morphology of the effects of MXC on left femur. At the end, took the bone histomorphomerey, bone hydroxyproline(B-HOP)and bone calcium to make the measurement and comparison. RESULTS:Compared with normal control mice, three doses of MXC can induce the decrease of femoral bone weight and the short transverse diameter. Bone-hydroxyproline content decreased remarkably, so did the bone-Ca. The thymus of the mice were atrophy. CONCLUSION:Three dosages of retinoic acid in mice can induce osteoporosis with the lessening of bone mass.
- [1]陈方,吴铁,崔燎.糖尿病性骨质疏松与骨羟脯氨酸含量关系的探讨[J].2002,(2).
- [2]王晓蓉,陈必良,马向东,等.甲氧滴滴涕对孕鼠生殖及其胎鼠发育的影响[J].2007,(7).
- [3]赵国军,文建国,杨静,等.甲氧滴滴涕对雄性生殖系统的氧化损伤作用[J].2005,(5).
- [4]常飞,陈必良,马向东,等.甲氧滴滴涕对雌性大鼠血清雌激素水平及卵巢抗氧化系统功能的影响[J].2007,(6).
- [5]Shegunova P,Klanova J,Holoubek I.Residues of organochlorinated pesticides in soils from the Czech Republic[J].2007,146(1).
- [6]Ingermann RL,Amstislavsky SY,Eroschenko VP,etc.Altered behaviors in male mice, male quail, and salamander larvae following early exposures to the estrogenic pesticide methoxychlor.[J].2002,24(1).
- [7]主编龚非力.医学免疫学[M].2003.
- [8]Zachow R,Uzumcu M.The methoxychlor metabolite, 2,2-bis-(p-hydroxyphenyl)-1,1,1-trichloroethane, inhibits steroidogenesis in rat ovarian granulosa cells in vitro.[J].2006,22(4).
- [9]Ross SM,You L,Fryczynski MW,etc.Combined effects of dietary phytoestrogen and synthetic endocrine-active compound on reproductive development in Sprague-Dawley rats: genistein and methoxychlor.[J].2002,66(1).
- [10]吴波,徐冰,黄添友,等.维A酸致大鼠骨质疏松模型与机理研究[J].1996,(4).