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Experimental research of histological difference between tissue-engineered skin and normal human skin

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Author:
No author available
Journal Title:
JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY
Issue:
24
DOI:
10.3321/j.issn:1000-2790.2009.24.006
Key Word:
组织工程皮肤;正常皮肤;再生;tissue-engineered skin;normal skin;regeneration

Abstract: AIM:To study the differences in histology of the tissue-engineered skin and normal human skin.METHODS:The bilayer skin replacement waft constructed by tissue engineering method,compared with the normal human skin by histological and immunohistochemistry methods.RESULTS:There were some differences in tissue-engineered skin and the normal skin.Epidermis rete pegs were presented only in the normal skin,CK19 was negative in the matured tissue engineered-skin,but both CK10 and pan-CK were positively expressed in tissue-engineered skin and the normal skin.Epithelium structure by TEM wag similar to the normal skin.CONCLUSION:The dermo-epidermal junction in tissue-engineered skin was less tighter than normal skin,may be due to the absence of epidermis rete pegs,epidermal cells had difierentiated.

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