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Immunosuppressive effects of emodin on skin transplantation in mice
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- Author:
- No author available
- Journal Title:
- JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY
- Issue:
- 4
- DOI:
- 10.3321/j.issn:1000-2790.2009.04.005
- Key Word:
- 大黄素;皮肤移植;白细胞介素2;免疫抑制;小鼠
Abstract： 目的:研究大黄素对小鼠皮肤移植的免疫抑制作用,探讨其町能的作用机制.方法:建立小鼠C57BL/6→BALB/c异体皮肤移植模型.以大黄素和环孢素A(CsA)分别灌胃,观察不同药物及药物浓度对小鼠皮肤移植物存活时问的影响.采用ELISA法检测大黄索和CsA对皮肤移植小鼠血浆IL-2表达水平的影响.组织学观察不同药物浓度对移植物病理变化的影响.结果:大黄素显著降低小鼠血浆内IL-2的浓度,同时伴有移植物的存活时间的延长.组织学观察发现大黄素可以减轻移植排斥反应的强度,其作用表现出量效依赖性,并与CsA具有协同性.结论:大黄素能够减轻C57BL/6→BALB/c异体皮肤移植的排斥反应强度,其作用机制可能与抑制IL-2的分泌有关.
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