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Effects of short-term running exercise on spatial learning capacity of middle-aged and aged rats
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- Author:
- No author available
- Journal Title:
- JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY
- Issue:
- 2
- DOI:
- 10.3321/j.issn:1000-2790.2009.02.003
- Key Word:
- 大鼠;空间学习能力;跑步训练;morris水迷宫
Abstract： 目的:探讨跑步训练对中老年及老年雌、雄性大鼠空间学习能力的作用.方法:将14 mo龄和24 mo龄的雌、雄性SD大鼠随机分为跑步训练组与空白对照组,前者进行跑步训练4 mo,后者在普通环境中饲养4 mo后,测试其在Morris水迷宫中的表现.结果:跑步训练至18 mo龄的雌性大鼠空间学习能力显著强于同月龄的空白对照组,但跑步训练至18mo龄的雄性大鼠空间学习能力与空白对照组相比并无显著性的差异.跑步训练至28 mo龄的雌、雄性大鼠空间学习能力与空白对照组相比均不存在显著性的差异.结论:短期跑步训练可使中老年雌性大鼠的空间学习能力显著提高,这一结论为今后运用跑步锻炼等手段来延缓老年人大脑功能下降的进程提供了重要的理论依据.
- [1]杨姝,李琛,张伟,等.大鼠大脑白质及白质内有髓神经纤维老年性改变的体视学研究[J].2007,(6).
- [2]Perrig-Chiello,P,Perrig,WJ,Ehrsam,R,etc.The effects of resistance training on well-being and memory in elderly volunteers.[J].1998,27(4).
- [3]H L, Hawkins,A F, Kramer,D, Capaldi.Aging, exercise, and attention.[J].1992,7(4).
- [4]J, Botwinick,L W, Thompson.A research note on individual differences in reaction time in relation to age.[J].1968,112(1st Half).
- [5]C.A. Barnes,M.J. Forster,M. Fleshner,etc.Exercise does not modify spatial memory, brain autoimmunity, or antibody response in aged F-344 rats[J].1991,12(1).
- [6]Li C,Yang S,Wang W,etc.Sex differences in the white matter and myelinated nerve fibers of Long-Evans rats.[J].2008,1216.
- [7]J, Botwinick,L W, Thompson.Age difference in reaction time: an artifact?[J].1968,8(1).
- [8]Sasvari M,Goto S,Nakamoto H,etc.Regular exercise improves cognitive function and decreases oxidative damage in rat brain.[J].2001,38(1).
- [9]Ozdemir D,Kayatekin BM,Gonenc S,etc.The effects of regular aerobic exercise in adolescent period on hippocampal neuron density, apoptosis and spatial memory.[J].2005,383(3).
- [10]Cotman CW,Pop V,Perreau VM,etc.Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer's disease.[J].2005,25(17).
- [11]Parachikova AI,Cotman CW,Nichol KE.Three weeks of running wheel exposure improves cognitive performance in the aged Tg2576 mouse.[J].2007,184(2).