You Position: Home > Paper
Expressions of NDRG2 and PKC-α mRNA in human glioma and their correlation
( views:185, downloads:4 )
- Author:
- No author available
- Journal Title:
- JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY
- Issue:
- 9
- DOI:
- 10.3321/j.issn:1000-2790.2008.09.004
- Key Word:
- 神经胶质瘤;NDRG2基因;蛋白激酶C-α;实时定量PCR
Abstract： 目的:研究胶质瘤中蛋白激酶PKC-α mRNA表达与NDRG2 mRNA表达的相关性,寻找可能与NDRG2相互作用的上下游分子.方法:用实时定量PCR技术检测26例脑胶质瘤及相应瘤旁组织中NDRG2和PKC-α mRNA表达量.结果:26例脑胶质瘤NDRG2 mRNA表达低于瘤旁组织(0.95±0.16 vs1.54±0.18,P<0.05),PKC-α mRNA表达高于瘤旁组织(1.23±0.11 vs 0.97±0.18,P<0.05),且随胶质瘤恶性程度增高,NDRG2表达逐渐减少(P<0.05),PKC-α表达有逐渐增加的趋势.NDRG2与PKC-α表达无相关(P>0.05).结论:NDRG2,PKC-α可能与胶质瘤的发生发展及恶性演变有关,在mRNA表达水平,还不能认为NDRG2与PKC-α之间有相关性.
- [1]LI BO YAO,YAN CHUN DENG,SHU JUN LI,etc.N-Myc downstream-regulated gene 2 (NDRG2) is a negative regulator of cell growth and its expression is decreased in cancers[J].2002,(3).
- [2]李剑,刘新平,林树新,等.一种新的抑癌候选基因--NDR2在人类正常组织及相应肿瘤中的表达[J].2002,(2).
- [3]Dennis, J. U.,Dean, N. M.,Bennett, C. F.,etc.Human melanoma metastasis is inhibited following ex vivo treatment with an antisense oligonucleotide to protein kinase C-�[J].1998,128(1).
- [4]Garcia-Morales P,Castro-Galache MD,Garcia EC,etc.Protein kinase C-alpha antagonizes apoptosis induction by histone deacetylase inhibitors in multidrug resistant leukaemia cells.[J].2007,39(10).
- [5]Yanchun, Deng,Libo, Yao,Ling, Chau,etc.N-Myc downstream-regulated gene 2 (NDRG2) inhibits glioblastoma cell proliferation.[J].2003,106(3).