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Effect of chronic multiple stress on the expression of HAP1 in the stomachus pyloricus of rats
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- Author:
- No author available
- Journal Title:
- JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY
- Issue:
- 22
- DOI:
- 10.3321/j.issn:1000-2790.2007.22.004
- Key Word:
- 慢性复合应激;亨廷顿蛋白相关蛋白1;幽门;大鼠
Abstract： 目的:探讨慢性复合应激大鼠胃幽门内分泌细胞亨廷顿蛋白相关蛋白1(HAP1)表达的变化及其意义.方法:大鼠12只随机分为慢性复合应激组和正常对照组.应激组动物进行6 wk的垂直旋转、睡眠剥夺、捆绑(6 h/d)和夜间光照等慢性复合性应激试验;实验结束后,所有动物采用免疫组织化学和Western Blot等方法检测胃幽门内分泌细胞内HAP1蛋白表达的变化.结果:HAP1在大鼠胃幽门主要表达在胃泌素细胞中.与对照组相比,慢性复合应激组大鼠胃幽门内分泌细胞内HAP1的表达增强(P＜0.05).结论:慢性复合性应激大鼠HAP1在胃幽门胃泌素细胞的表达加强.
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