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Janus kinase Inhibitor AG490 and DDP suppress activation of STAT3 signaling pathway in laryngeal cancer cells
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- Author:
- No author available
- Journal Title:
- JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY
- Issue:
- 21
- DOI:
- 10.3321/j.issn:1000-2790.2007.21.003
- Key Word:
- 喉癌;增殖;凋亡
Abstract： 目的:探讨Stat3信号转导通路在药物治疗喉癌中的作用机制.方法:应用JAK激酶抑制剂AG490与顺铂(DDP)处理喉癌细胞系Hep-2细胞,Western Blot检测Stat3信号转导通路成员表达,MTT法检测细胞增殖状态,流式细胞技术检测细胞周期与凋亡.结果:AG490与DDP可以抑制喉癌细胞增殖,促进喉癌细胞凋亡(P=0.008),联合应用AG490与DDP可以起协同作用,喉癌细胞Stat3信号转导通路成员表达与活性明显下降.结论:JAK激酶抑制剂AG490与DDP联合应用可能为治疗喉癌提供了新的理论基础.
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