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Effects of bone marrow stem cell transplantation at different time on heart function of rats with myocardial infarction
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- Author:
- No author available
- Journal Title:
- JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY
- Issue:
- 5
- DOI:
- 10.3321/j.issn:1000-2790.2007.05.005
- Key Word:
- 骨髓间充质干细胞;心肌梗死;静脉移植;心功能
Abstract： 目的:探讨心肌梗死后骨髓间充质干细胞(MSCs)移植的最佳时间. 方法: 结扎大鼠左冠状动脉制备心肌梗死模型,将分离培养的大鼠MSCs经尾静脉分别移植到1 d, 1, 2, 4 wk移植组体内(各组n=10),对照组则注入等量培养液(n=10). 4 wk后测定左心功能指标和心肌缺血梗死面积. 结果: 心肌梗死后1 d移植组左心功能和心肌缺血梗死面积与对照组无明显差别(P＞0.05),而1, 2, 4 wk移植组与1 d移植组对比左心功能明显改善(P＜0.05),心肌缺血梗死面积显著减小(P＜0.05),其中2 wk移植组效果优于1 wk移植组和4 wk移植组(P＜0.05). 结论:心肌梗死后1～2 wk亚急性期进行细胞移植效果最好.
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