You Position: Home > Paper
Expressions of ezrin,c-Met and ICAM-1 proteins in gastric carcinoma and their significances
( views:127, downloads:0 )
- Author:
- No author available
- Journal Title:
- JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY
- Issue:
- 4
- DOI:
- 10.3321/j.issn:1000-2790.2007.04.005
- Key Word:
- 胃肿瘤;ezrin;c-Met;胞间粘附分子-1;免疫组织化学
Abstract： 目的:探讨ezrin,c-Met及ICAM-1在胃癌组织中的表达及意义.方法:应用免疫组化检测ezrin,c-Met及ICAM-1在正常胃黏膜(n=15),不典型增生胃黏膜(n=50)及胃癌组织(n=75)中的表达.结果:正常胃黏膜、不典型增生胃黏膜及胃癌组织中,ezrin和c-Met阳性率有递减趋势,组间差异有统计学意义(χ2=33.319,P＜0.001; χ2=19.913,P＜0.001); ICAM-1蛋白阳性表达率有递增趋势,组间差异有统计学意义(χ2=16.409,P＜0.001).Fisher精确概率检验显示在不同的肿瘤大小、浸润深度和淋巴结转移组内ezrin,c-Met及ICAM-1阳性表达率组内差异有统计学意义(P＜0.05),而在年龄、性别和脉管侵犯组内差异无统计学意义(P＞0.05). Spearman等级相关分析显示ezrin与c-Met表达呈正相关(r=0.880,P＜0.05),ezrin与ICAM-1表达呈负相关(r=-0.735,P＜0.05),c-Met与ICAM-1表达无相关性.结论:ezrin与c-Met的缺失以及ICAM-1的过表达与胃癌的发生发展及浸润转移有关.
- [1]Meltzer PS,Helman L,Khanna C,etc.Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulators.[J].2004,10(2).
- [2]Edwards K,Fehon RG,Bretscher A.ERM proteins and merlin: integrators at the cell cortex.[J].2002,3(8).
- [3]Patrick W. B. Derksen,M. Adhiambo Witlox,Elisabeth Bloemena,etc.Suppression of tumor growth, invasion and angiogenesis of human gastric cancer by adenovirus-mediated expression of NK4[J].2004,6(3).
- [4]Smith WJ,Nassar N,Bretscher A,etc.Structure of the active N-terminal domain of Ezrin. Conformational and mobility changes identify keystone interactions.[J].2003,278(7).
- [5]Olomu O,Gorlick R,Helman LJ,etc.The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis.[J].2004,10(2).
- [6]Varner J,Jin H.Integrins: roles in cancer development and as treatment targets.[J].2004,90(3).
- [7]J, Mathew,J E, Hines,J O, Obafunwa,etc.CD44 is expressed in hepatocellular carcinomas showing vascular invasion.[J].1996,179(1).