You Position: Home > Paper

Localization of NMDA and AMPA-type glutamate receptors in forebrain ventricular membrane and subventricular zone of adult rats

( views:347, downloads:4 )
Author:
No author available
Journal Title:
JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY
Issue:
23
DOI:
10.3321/j.issn:1000-2790.2006.23.002
Key Word:
谷氨酸受体;NMDA受体;AMPA受体;室管膜;免疫组织化学

Abstract: 目的:观察前脑室管膜及室管膜下区N-甲基-D-天门冬氨酸(NMDA)和使君子酸(AMPA)型谷氨酸受体的分布. 方法:应用成年SD大鼠前脑切片免疫组织化学方法,显示NMDA和AMPA受体六种亚基的细胞定位. 结果:在室管膜及室管膜下区有NMDA受体亚基NR1,NR2C及AMPA受体亚基GluR1,GluR2/3,GluR4免疫反应阳性产物的分布,免疫阳性产物则均匀地分布在细胞质或细胞膜. 半定量分析表明NR1和GluR4阳性细胞的数目和染色密度均高于NR2C,GluR1和GluR2/3阳性细胞. 结论:结合以往研究,NMDA和AMPA受体亚基在大鼠前脑室管膜及室管膜下区定位结果提示NMDA和AMPA受体可能参与该区域神经发生等功能活动的调节.

WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn