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Study on FRAXF gene polymorphism in children with mental retardation in Qinba mountain district
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- Author:
- No author available
- Journal Title:
- JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY
- Issue:
- 8
- DOI:
- 10.3321/j.issn:1000-2790.2006.08.005
- Key Word:
- 多态现象(遗传学);儿童;智力;FRAXF
Abstract： 目的:研究秦巴山区儿童FRAXF位点多态性与儿童智力之间的关系. 方法: 应用多聚酶链式反应(PCR)结合聚丙烯酰胺电泳凝胶分析系统分析技术对84例智力低下儿童及对照组72例智力正常儿童的FRAXF基因多态性进行检测比较,探讨FRAXF基因多态性对儿童智力的影响. 结果: 病例组共检出该位点19个等位基因,重复次数范围为7～28. 对照组共检出该位点21个等位基因,重复次数范围在1～20. 通过χ2检验,两组之间等位基因多态性分布差异显著(χ2=14.05, P《0.005). 结论: 结果提示FRAXF基因的不稳定性可能与儿童的智力发育有关. FRAXF基因可能是儿童智力低下的易感基因之一.
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