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Expression of bone morphogenetic protein and its significance during distraction osteogenesis following tibial osteotomy
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- Author:
- No author available
- Journal Title:
- JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY
- Issue:
- 8
- DOI:
- 10.3321/j.issn:1000-2790.2006.08.004
- Key Word:
- 骨形态发生蛋白质类;骨生成,内脱位;骨再生;骨不连接
Abstract： 目的:探讨快速延长成骨过程中骨形成蛋白(BMP)的表达及意义. 方法: 制作兔胫骨截骨快速延长动物模型,分别于延长第5, 10, 15, 20, 30和40日在延长区取材,以抗骨形成蛋白单克隆抗体(BMP-McAb)行SP法免疫组化染色光镜观察. 结果: 在骨延长的整个过程中均有BMP的表达,不同时相BMP表达的部位不同. 除炎症细胞、类骨样组织及骨小梁外,几乎所有细胞及组织均有BMP存在. 间充质细胞、软骨细胞、成骨细胞、骨细胞、骨髓细胞BMP呈高表达. 结论: BMP在骨延长成骨过程中发挥着重要作用. BMP表达量不足可能是导致快速骨延长骨不连接的重要因素.
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