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Effect of Gliclazide on mRNA expression of ATP-sensitive potassium channels in myocardium of diabetic rats
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- Author:
- No author available
- Journal Title:
- JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY
- Issue:
- 1
- DOI:
- 10.3321/j.issn:1000-2790.2006.01.003
- Key Word:
- 糖尿病;心肌;ATP敏感性钾通道;格列齐特
Abstract： 目的:观察格列齐特(Gliclazide)对糖尿病大鼠心肌组织ATP敏感性钾通道mRNA表达的影响. 方法:采用链脲佐菌素小剂量ip结合高脂饮食饲养形成2型糖尿病大鼠模型,随机分为糖尿病对照组、糖尿病胰岛素治疗组和糖尿病格列齐特组,另设正常对照组. RT-PCR检测ATP敏感性钾通道mRNA表达. 结果:糖尿病组、糖尿病胰岛素治疗组和正常对照组ATP敏感性钾通道mRNA表达水平无差异(P>0.05). 格列齐特治疗组ATP敏感性钾通道mRNA表达水平较正常对照组和糖尿病组无明显变化(P>0.05). 结论:链脲佐菌素诱导的实验性糖尿病不影响心肌ATP敏感性钾通道mRNA表达水平;治疗剂量的格列齐特对ATP敏感性钾通道mRNA的表达无影响.
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