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Targeted drug delivery system-the highlight of pharmaceutics

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Author:: No author available

Journal Title:: JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY

Issue:: 22

DOI:: 10.3321/j.issn:1000-2790.2005.22.001

Key Word:: 靶向给药;药剂学;药物载体

Abstract： @@ 0 引言常规剂型的药物经静脉、口服或局部注射后,药物分布于全身,真正到达治疗靶区的药物量仅为给药量的小部分,而大部分药物在非靶区的分布不仅无治疗作用,还会带来毒副作用.

Reference

[1]彭应旭,庄燕黎,谬工铁.骨髓靶向柔红霉素毫微粒的研究[J].2000,(2).
[2]张志荣,王建新.脑靶向3′,5′-二辛酰基-5-氟脲嘧啶脱氧核苷药质体研究[J].2001,(10).
[3]薛克昌,张三奇,顾宜,等.十六酸拉米夫定酯固体脂质纳米粒的肝靶向研究[J].2004,(1).
[4]韩勇,易以木.纳米粒肝靶向作用机制的研究进展[J].2002,(12).
[5]方华圣,洪梅,张树政,等.表皮生长因子受体介导的肿瘤靶向基因治疗的一种新策略[J].2004,(6).
[6]张莉,向东,洪诤,等.肝靶向去甲斑蝥素微乳的研究[J].2004,(8).
[7]周四元,梅其炳,赵德化.地塞米松·葡聚糖的合成及其肠内容物中的转释特性[J].2000,(4).
[8]奚苗苗,张三奇,顾宜,等.果胶酮洛芬前药的合成及体外评价[J].2004,(14).
[9]李剑平,窦科峰,陈勇,等.半乳糖基化壳聚糖肝靶向性基因转导的体内实验[J].2005,(7).
[10]Schacht, E.,Gevaert, A.,Kenawy, E. R.,etc.Polymers for colon specific drug delivery[J].1996,39(2).
[11]徐凤华,蒋雪涛.葡聚糖-表柔比星偶合物的制备和性质研究[J].2000,(7).
[12]V H, van Der Velden,J G, te Marvelde,P G, Hoogeveen,etc.Targeting of the CD33-calicheamicin immunoconjugate Mylotarg (CMA-676) in acute myeloid leukemia: in vivo and in vitro saturation and internalization by leukemic and normal myeloid cells.[J].2001,97(10).
[13]王剑红,陆彬,胥佩菱,等.肺靶向米托蒽醌明胶微球的研究[J].1995,(7).
[14]Z R, Zhang,W J, Qian.[Study on mitoxantrone albumin microspheres for liver targeting].[J].1997,32(1).
[15]El Sherief H,Al Tayeb A,Sheha M,etc.New carrier for specific delivery of drugs to the brain.[J].2003,11(8).
[16]Uekama K.,Kamada M.,Hirayama F.,etc.Colon-specific delivery of prednisolone-appended alpha-cyclodextrin conjugate: alleviation of systemic side effect after oral administration[J].2002,79(1).
[17]M K, Chourasia,S K, Jain.Pharmaceutical approaches to colon targeted drug delivery systems.[J].1900,6(1).
[18]Theresa M, Allen,Pieter R, Cullis.Drug delivery systems: entering the mainstream.[J].2004,303(5665).
[19]J H, Wang,B, Lu,P L, Xu,etc.[Studies on lung targeting gelatin microspheres of mitoxantrone].[J].1995,30(7).
[20]Hudis Clifford,Pierri MaryKathryn,Keefe Deborah,etc.Cardiac dysfunction in the trastuzumab clinical trials experience.[J].2002,20(5).
[21]Favier R.,Rousseau C.,Douay L.,etc.Polyalkylcyanoacrylate nanoparticles as carriers for granulocyte-colony stimulating factor (G-CSF)[J].1998,52(1).
[22]Fang KQ,Wang XY,Gu Y,etc.Study on the characteristics of pectin-ketoprofen for colon targeting in rats.[J].2005,298(1).
[23]张志荣,钱文璟.肝靶向米托蒽醌白蛋白微球的研究[J].1997,(1).
[24]Wu WM,Chen P,Prokai L,etc.Strategies to target kyotorphin analogues to the brain.[J].1998,41(20).
[25]J. A. Reddy,V. M. Allagadda,C. P. Leamon.Targeting Therapeutic and Imaging Agents to Folate Receptor Positive Tumors[J].2005,6(2).
[26]Skidan IN,Antropov AS,Kivman GY,etc.Significant transport of doxorubicin into the brain with polysorbate 80-coated nanoparticles.[J].1999,16(10).
[27]F, Ciardiello,R, Bianco,V, Damiano,etc.Antitumor activity of sequential treatment with topotecan and anti-epidermal growth factor receptor monoclonal antibody C225.[J].1999,5.
[28]Zenker D,Kreuter J,Begley D,etc.Polysorbate-80 coating enhances uptake of polybutylcyanoacrylate (PBCA)-nanoparticles by human and bovine primary brain capillary endothelial cells.[J].2000,12(6).