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Effect of sodium valproate on ectopic spontaneous discharge of injured dorsal root ganglion neurons in rats
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- Author:
- No author available
- Journal Title:
- JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY
- Issue:
- 20
- DOI:
- 10.3321/j.issn:1000-2790.2005.20.001
- Key Word:
- 神经节,脊;异位自发放电;丙戊酸;神经病理性痛
Abstract： 目的: 探讨丙戊酸钠(sodium valproate, VPA)对损伤背根节神经元异位自发放电的影响及其时间和剂量关系. 方法: 分离背根单纤维,引导来自损伤背根节(dorsal root ganglion, DRG)神经元的异位自发放电,观察不同浓度VPA对放电频率和放电模式的影响. 结果: VPA可抑制异位自发放电,降低其放电数,并具有剂量依赖关系. 结论: 局部应用VPA可抑制DRG神经元自发放电,这可为外周应用VPA进行镇痛治疗提供依据.
- [1]Y, Xie,J, Zhang,M, Petersen,etc.Functional changes in dorsal root ganglion cells after chronic nerve constriction in the rat.[J].1995,73(5).
- [2]Sindrup SorenH,Jensen TroelsS.Pharmacotherapy of trigeminal neuralgia.[J].2002,18(1).
- [3]S. J. Hu,Y. F. Gong,W. Ren,etc.Period-Adding Bifurcation with Chaos in the Interspike Intervals Generated by an Experimental Neural Pacemaker[J].1997,7(8).
- [4]S.K. KOCHAR,P. GARG,N. RAWAT,etc.Divalproex sodium in the management of post-herpetic neuralgia: a randomized double-blind placebo-controlled study[J].2005,98(1).
- [5]K. V. Sørensen.Valproate: a new drug in migraine prophylaxis[J].1988,78(4).
- [6]Johannessen CU.Mechanisms of action of valproate: a commentatory.[J].2000,37(2).
- [7]Xing JL,Hu SJ.An experimental model for chronic compression of dorsal root ganglion produced by intervertebral foramen stenosis in the rat.[J].1998,77(1).
- [8]R.P. AGRAWAL,R. BENIWAL,P. GARG,etc.Sodium valproate for painful diabetic neuropathy: a randomized double-blind placebo-controlled study[J].2004,97(1).