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Effect of aconitine on spontaneous activities from injured dorsal root ganglion neurons
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- Author:
- No author available
- Journal Title:
- JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY
- Issue:
- 13
- DOI:
- 10.3321/j.issn:1000-2790.2005.13.001
- Key Word:
- 乌头碱;背根节;电生理学
Abstract： 目的:研究钠通道失活门抑制剂乌头碱(aconitine)对受损背根节(DRG)神经元不同模式的背景放电的作用.方法:在大鼠DRG慢性压迫模型上记录A类单纤维自发放电,观察和分析乌头碱作用下动作电位峰峰间期序列(ISI)的变化及特征.结果:在大鼠L5DRG浸浴乌头碱(10～200μmol/L)后,80%簇放电(bursting)和70%不规则放电(irregular)逐渐转化为持续的周期放电;91%周期放电(period)只表现为放电频率的不断增加,并没有发生放电模式的转化.对于静息的神经元,乌头碱则不能引发放电.结论:在阻断钠通道失活门之后,受损DRG神经元的自发放电可以发生模式转化,并且乌头碱对DRG神经元的作用具有活动依赖性.
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