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Ageing lens and development of cataract

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Author:: No author available

Journal Title:: JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY

Issue:: 2

DOI:: 10.3321/j.issn:1000-2790.2005.02.001

Key Word:: 老化;白内障;构象性疾病;翻译,遗传;晶体

Abstract：晶状体老化的结构性改变包括晶状体质量和密度的增加、晶状体前囊膜的增厚和晶状体上皮细胞密度的降低等.荧光发生素在晶状体中积累,可能主要参与老化过程中晶状体变黄和荧光色素增加.老化晶状体中蛋白质翻译后修饰和蛋白质去折叠增加,最终导致蛋白质凝聚和酶失活.晶状体特有的氧化清除剂和分子伴侣作为强大的防御系统,在老化过程中逐渐衰退,加剧了翻译后修饰造成的损伤.白内障是晶状体老化的最终结果,可作为其他组织器官衰变的信号.分子伴侣能解救构象性疾病,使晶状体重要的代谢酶‘起死回生'.

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