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Serial diffusion-weighted MR imaging and 1H-MRS around hematoma in pigs with frontal lobe hemorrhage
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- Author:
- No author available
- Journal Title:
- JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY
- Issue:
- 21
- DOI:
- 10.3321/j.issn:1000-2790.2004.21.005
- Key Word:
- 猪;脑出血;脑水肿;弥散加权成像;质子波谱分析;血-脑屏障
Abstract： 目的:阐明脑出血1～7 d时血肿周围水肿的演变规律和性质. 方法:将15只质量10～15 kg的仔猪动脉血2.5 mL注入右侧额叶,在24 h(n=15),72 h(n=9)和7 d(n=5)后用1.5T MR行FLAIR(液体衰减返转恢复快速自旋回波序列), DWI(弥散加权成像)和血肿周围组织的1H-MRS(质子波谱分析); 病理观察4只动物24 h时血肿周围组织对伊文思蓝的外渗以确定血脑屏障的完整性,同时对各时间点处死动物的脑组织进行常规病理观察. 结果:FLAIR显示24 h至7 d时血肿周围组织水肿严重,局部平均表观弥散系数(ADC)升高,24 h时灶周大量伊文思蓝外渗,但水肿区1H-MRS分析除1例大量出血者外均无乳酸峰. 结论:中等量脑出血时血肿周围以血管源性脑水肿为主,并未发现缺血性损害,但不排除大量出血时存在缺血性损害的可能性.
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